Maternal-fetal cross talk through cell-free fetal DNA, telomere shortening, microchimerism, and inflammation
نویسندگان
چکیده
منابع مشابه
Fetal cell microchimerism in the maternal heart: baby gives back.
In this issue of Circulation Research, Kara et al1 present an elegant series of experiments demonstrating that after murine maternal myocardial infarction, fetal cells engraft and differentiate into endothelial cells, smooth muscle cells, and cardiomyocytes at the site of injury. These cells, when isolated and cocultured with neonatal cells, appear to be capable of differentiating into beating ...
متن کاملApplications of Cell-Free Fetal DNA in Maternal Serum
Cell-free fetal DNA (cffDNA) is available in the maternal circulation throughout pregnancy and can be used for noninvasive prenatal diagnosis including, determination of fetal sex, identification of specific single gene disorders, typing of fetal blood groups (RhD), paternity determination and potentially routine use for Down’s syndrome (DS) testing of all pregnancies. I searched published lite...
متن کاملIntroducing a New and Simple Protocol for Capillary Electrophoresis of Cell Free Fetal Double Stranded DNA
Isolation of cell free fetal DNA (cffDNA) from maternal serum usually leads to very low concentrations of DNA impeding further resolving through conventional methods of electrophoresis. Although several protocols have been described for capillary electrophoresis (CE) of double stranded DNA, they usually need using special polymers or coated capillaries which degrade over time. Herein, we propos...
متن کاملFetal microchimerism and cancer.
The persistence of fetal stem cells with multilineage potential in women who have been pregnant, a phenomenon known as fetal microchimerism, is emerging as a potential contributing factor in certain diseases, including cancer. For example, fetal microchimerism has been implicated in autoimmune disease, wound healing, and cancer. Studies of this phenomenon may provide a novel perspective on canc...
متن کاملCritically Appraised Topic Fetal RHD genotyping in maternal blood using cell-free fetal DNA
The discovery of cell-free fetal DNA (cffDNA) in maternal plasma has opened up new possibilities for non-invasive prenatal diagnosis (NIPD). Real-time PCR protocols as well as MALDI-TOF mass spectrometry techniques have been developed to determine fetal RHD genotype on maternal plasma. In several European centers, NIPD for fetal RHD has become the standard of care for evaluation of anti-D allo-...
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ژورنال
عنوان ژورنال: American Journal of Reproductive Immunology
سال: 2018
ISSN: 1046-7408
DOI: 10.1111/aji.12851